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. 2017 Aug 23;7:9169. doi: 10.1038/s41598-017-08693-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Viscoelastic modulus, G, at 5 Hz measured by the LSR sensor is plotted as a function of coagulation time from blood samples obtained from a normal patient (with reported normal laboratory PT/INR value) and a patient on Coumadin medication. The G trace measured in real-time during coagulation was analyzed to estimate the PT and INR values. The blood sample from normal patient showed shorter PT_LSR value (12 s) in comparison to the blood sample from the patient on Coumadin therapy (51 s). The corresponding PT_Lab values obtained from standard laboratory testing were 14 s and 43 s for the normal and Coumadin treated patient respectively.