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. 2017 Aug 23;7:9257. doi: 10.1038/s41598-017-09378-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representation of the subgraph obtained from the PID-NCI database. CD40, IL6 and IGF1 (the nodes in the top portion of the graph) are the 3 queried pathways. The 529 genes that are differentially expressed across all profiles are merged for this representation in the node “Gene set”. The 5 top-ranked nodes according to their FS are labeled in bold type and colored in yellow. We used the same syntax for all nodes in this study. The edges from the “Gene set” node to proteins have been deleted for the sake of clarity.