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. 2017 Aug 23;7:9192. doi: 10.1038/s41598-017-09078-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MET and EGFR inhibition in EGFR mutation cell line H1975. (A) CBL, MET, p-MET, EGFR, and p-EGFR protein expression in H1975 CBL knockdown cells. Protein expression was quantified and indicated with the fold change numbers shown below each immunoblot in comparison with parental H1975 cells. Each protein lysates of separated blot of were collected in the same time period for and the lysates were loaded in one gel per antibody staining. (p: parental, c: sh-control). (B) MET inhibitor SU11274, (C) EGFR inhibitor erlotinib, and (D) SU11274 and erlotinib combination were used to treat H1975, H1975 sh-control, and H1975 sh-CBL cells with variant dosages for 24 hr. *p < 0.05, **p < 0.01. RFU: relative fluorescence units.