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. 2017 Aug 23;7:9192. doi: 10.1038/s41598-017-09078-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tumor growth of CBL knockdown cells in mouse xenograft model. (A) Tumor was assessed three times a week. sh-control (con) of A549 and H358 cells showed more rapid growth of tumor than sh-CBL (CBL) cells. (B) Tumor weight of sh-CBL groups in A549 and H358 cells showed a significant difference compared with sh-control (* p < 0.05). (C) Photograph of tumors from 4 mice of sh-control and sh-CBL groups in A549 and H358 cells. (D) H&E staining of primary tumors from sh-control and sh-CBL groups in A549 and H358 cells at 10x, 20x, and 60x magnifications. (E) Metastasis study of CBL knockdown cells in vivo. H&E staining of lung tumors showed more tumor metastasis results by pathologist’s reading from the subcutaneous injection site to the lung in both A549 and H358 sh-CBL cells than in sh-control cells. Metastatic tumors shown by black arrows.