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. 2017 Aug 23;7:9265. doi: 10.1038/s41598-017-08920-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GSNO induces insulin resistance in hypothalamus. Cumulative food intake (A) and body weight change (B) of GSH or GSNO treated rats. Real-time analysis of NPY, AgRP, POMC and CART, expression generated from GSH or GSNO treated rats (C). Biotin switch method analysis for IRβ and Akt S-nitrosation in rats treated with GSNO (D). Cumulative food intake (E) and body weight change (F) in insulin or insulin plus GSNO treated rats. Data are presented as mean ± SEM, *p < 0.05 vs. GSH -injected rats; **p < 0.01 vs. GSNO treated group (n = 10–15 animals per group).