Table 1.
Targeted endonucleases (CRISPR, TALEN, ZFN) have been used in many species to generate somatic and germline modifications in organisms
| Organism | Endonuclease targeting system | Reference |
|---|---|---|
| Vertebrates | ||
| Axolotl | CRISPR, TALEN | Fei et al. (2014), Flowers et al. (2014) |
| Catfish | CRISPR, TALEN, ZFN | Dong et al. (2011), Dong et al. (2014), Li M et al. (2016) |
| Cattle | CRISPR, TALEN, ZFN | Wu et al. (2015), reviewed in Tang et al. (2015) |
| Frog | CRISPR, TALEN, ZFN | Reviewed in Shi et al. (2017) |
| Goat | CRISPR, TALEN | Reviewed in Menchaca et al. (2016) |
| Medaka | CRISPR, TALEN, ZFN | Ansai and Kinoshita (2014), Guan et al. (2014), Wang and Hong (2014) |
| Mouse | CRISPR, TALEN, ZFN | Reviewed in Sander and Joung (2014) |
| Monkey | CRISPR, TALEN | Niu et al. (2014), Wan et al. (2015) |
| Newt | TALEN | Hayashi T et al. (2014) |
| Pig | CRISPR, TALEN, ZFN | Sato et al. (2014), reviewed in Tang et al. (2015) |
| Rabbit | CRISPR, TALEN, ZFN | Flisikowska et al. (2011), Honda et al. (2015), Wang et al. (2014b) |
| Rat | CRISPR, TALEN, ZFN | Reviewed in Mashimo T (2014) |
| Rainbow trout | ZFN | Yano et al. (2012) |
| Sheep | CRISPR, TALEN, ZFN | Reviewed in Menchaca et al. (2016), Zhang et al. (2016a, b, c) |
| Tilapia | CRISPR, TALEN | Li et al. (2013a, b), Li et al. (2014) |
| Zebrafish | CRISPR, TALEN, ZFN | Reviewed in Auer et al. (2014) |
| Invertebrates | ||
| Butterfly | CRISPR, TALEN, ZFN | Market et al. (2016), Merlin et al. (2013) |
| Cricket | CRISPR, TALEN, ZFN | Awata et al. (2015), Watanabe (2012) |
| Freshwater flea | CRISPR, TALEN | Naitou et al. (2015), Nakanishi et al. (2014), Nakanishi et al. (2015) |
| Fruit fly | CRISPR, TALEN, ZFN | Reviewed in Lin et al. (2014) |
| Mosquito | CRISPR, TALEN, ZFN | Aryan et al. (2013), review in Reegan et al. (2017) |
| Plasmodium | CRISPR, TALEN, ZFN | Smidler at al. (2013), Straimer et al. (2012), reviewed in Singer and Frischknecht (2017) |
| Roundworm | CRISPR, TALEN, ZFN | reviewed in Gaj et al. (2013), Waaijers and Boxem (2014) |
| Sea squirt | CRISPR, TALEN, ZFN | Kawai et al. (2012), Sasaki et al. (2014), Treen et al. (2014) |
| Silkworm | CRISPR, TALEN, ZFN | Reviewed in Xu and O’Brochta (2015) |
| Plants | ||
| Barley | CRISPR, TALEN | Lawrenson et al. (2015), Wendt et al. (2013) |
| Bunchgrass | TALEN | Shang et al. (2013a) |
| Cabbage | CRISPR, TALEN | Lawrenson et al. (2015), Sun et al. (2013) |
| Corn | CRISPR, TALEN, ZFN | Char et al. (2015), Shukla et al. (2009), Somaratne et al. (2017) |
| Chlamydomonas | CRISPR, ZFN | Shin et al. (2016), Sizova et al. (2013) |
| Duncan grapefruit | CRISPR | Jia et al. (2016) |
| Liverwort | CRISPR | Sugano et al. (2014) |
| Petunia | CRISPR, ZFN | Marton et al. (2010), Zhang B et al. (2016a, b, c) |
| Rice | CRISPR, TALEN | Li et al. (2012), reviewed in Belhaj et al. (2013) |
| Sorghum | CRISPR | Jiang et al. (2013) |
| Soybean | CRISPR, TALEN, ZFN | Curtin et al. (2011), Haun et al. (2014), Jacobs et al. (2015) |
| Sugarcane | TALEN | Jung and Altpeter (2016) |
| Sweet orange | CRISPR | Jia and Wang (2014) |
| Thale cress | CRISPR, ZFN | Li et al. (2013a, b), Zhang F et al. (2010), Zhang Z et al. (2016 ) |
| Tobacco | CRISPR, TALEN, ZFN | Li et al. (2013a, b), Townsend et al. (2009), Zhang et al. (2013) |
| Wheat | CRISPR, TALEN | Shan et al. (2013b), Wang et al. (2014a) |