Table 1.
Demographic and clinical characteristics of chronic hepatitis B patients n (%)
| Characteristic | PNALT (n = 95) | PIALT1 (n = 86) | PIALT2 (n = 64) | Statistic | P value |
| Age (yr) | 34.5 ± 11.2 | 34.2 ± 12.5 | 36.5 ± 13.5 | 5.423 | 0.0211 |
| Sex | |||||
| Male | 70 (73.7) | 58 (67.4) | 46 (71.9) | 0.885 | 0.6422 |
| Female | 25 (26.3) | 28 (32.6) | 18 (28.1) | ||
| BMI | 23.4 ± 2.65 | 24.0 ± 3.6 | 24.25 ± 3.37 | 1.231 | 0.5431 |
| PLT (× 109/L) | 200.1 ± 60.3 | 196.8 ± 65.4 | 186.5 ± 74.5 | 6.364 | 0.0181 |
| PTA (%) | 99.6 ± 6.7 | 99.6 ± 8.7 | 102.3 ± 10.3 | 0.674 | 0.7741 |
| ALB (g/L) | 41.3 ± 3.4 | 41.6 ± 3.7 | 42.4 ± 4.1 | 1.536 | 0.5431 |
| ALT (U/L) | 21.4 ± 4.3 | 56.2 ± 19.4 | 113.6 ± 55.3 | 25.754 | < 0.0011 |
| AST (U/L) | 22.6 ±6.8 | 55.4 ± 16.6 | 124.5 ± 57.6 | 31.644 | < 0.0011 |
| APRI | 0.32 ± 0.14 | 0.61 ± 0.44 | 1.25 ± 0.62 | 284.92 | < 0.0011 |
| FIB-4 | 0.72 ± 0.36 | 1.12 ± 0.53 | 1.67 ± 0.84 | 56.37 | < 0.0011 |
| FibroScan (kPa) | 5.33± 2.45 | 7.36 ± 3.14 | 10.22 ± 5.53 | 46.34 | < 0.0011 |
| HBsAg [lg (IU/L)] | 4.41 ± 0.73 | 4.53 ± 0.88 | 4.38 ± 0.64 | 0.743 | 0.437 |
| HBV DNA [lg (IU/mL)] | 6.78 ± 2.13 | 6.53 ± 2.43 | 6.42 ± 2.54 | 0.864 | 0.2541 |
| ≥ 3, < 5 | 15 (15.8) | 11 (12.8) | 10 (15.6) | 0.384 | 0.8252 |
| ≥ 5 | 80 (84.2) | 75 (87.2) | 54 (84.4) | ||
| E antigen | |||||
| Positive | 42 (44.2) | 31 (36) | 29 (45.3) | 1.78 | 0.4112 |
| Negative | 53 (55.8) | 55 (64) | 35 (54.7) | ||
| Necroinflammatory score | 2.21 ± 2.14 | 3.47 ± 3.64 | 4.74 ± 3.65 | 23.43 | 0.001 |
| Minimal | 35 (32.4) | 20 (23.3) | 8 (12.5) | 18.69 | 0.005 |
| Mild | 44 (38) | 38 (44.2) | 27 (42.4) | ||
| Moderate | 15 (15.8) | 26 (30.2) | 22 (34.4) | ||
| Severe | 1 (0.9) | 2 (2.3) | 7 (10.9) | ||
| Fibrosis score | 1.53 ± 0.46 | 2.38 ± 1.27 | 2.85 ± 1.75 | 15.237 | 0.0051 |
| Minimal | 32 (33.7) | 18 (20.9) | 13 (20.3) | 13.275 | 0.0352 |
| Mild | 40 (42.1) | 40 (51.2) | 23 (35.9) | ||
| Moderate | 21 (22.1) | 24 (27.9) | 21 (32.8) | ||
| Severe | 2 (2.1) | 5 (5.8) | 7 (10.9) |
1
One-way analysis of variance;
2
Pearson χ2. APRI = [AST (U/L)/ULN × 100/PLT (109/L)]; FIB-4 = [age (yr) × AST (U/L)]/[PLT (109/L) × (ALT U/L)1/2].