Figure 1.

Schematic overview of the in vivo study design. Guinea pigs were sensitized to OVA at day 0 (sensitization 1) and day 7 (sensitization 2). Three weeks after the last sensitization, at day 28, animal groups were pre‐treated with either Budesonide (n = 10) or PPS (0.5 mg/kg, n = 10 or 5 mg/kg, n = 10) for 30 min prior to OVA or Saline challenge (control groups received PBS pre‐treatment, (n = 7 per control group). Changes in the late phase response were determined by analysis of nasal lavage fluid and histological nasal tissue (septum) at 8 h after allergen challenge.