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. 2017 Apr 19;5(3):218–232. doi: 10.1002/iid3.158

Figure 1.

Figure 1

HFE as an iron sensor and the TfR1/Tf cycle for cellular iron uptake. The TfR1 is located at the cell surface where it binds Tf‐bound iron. HFE is also located at the cell surface and competes with Tf for binding to TfR1. The TfR1/Tf or TFR1/HFE complex is internalized by clathrin‐dependent endocytosis before iron is released from the TfR1/HFE complex in endosomes acidified to a pH of 5.5. Iron is then exported from the endosomes to the cytosol through the DMT‐1 transporter and is typically stored as ferritin in the cytosol.