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HFE and classical MHC I molecules present homologous structures and are synthesized and folded within the endoplasmic reticulum. A) Structures of HLA‐A2 and HFE and binding sites to antigen presentation chaperones for HLA‐A2, as well as degree of conservation of these sites in HFE. B) Schema depicting the MHC I antigen presentation pathway as well as HFE synthesis, surface transport, and expression.
