Table 1.

The studies and mechanism of IL‐37 in cardiovascular diseases

Disease model	Effect	Reference
Atherosclerosis	↑M1→M2 ↓ NF‐κB, ↓ICAM‐1↓Inflammatory cytokines↓Calcification areas	26, 28, 38, 39
Myocardial infarction	↑Tregs, ↓MPO, ↓ROS↓Myocardial fibrosis↓Cardiomyocyte apoptosis↓Infarct size↑Left ventricular function	17, 44, 46
Ischemia/reperfusion (I/R)	↓Inflammation↑Tregs ↑FoxP3, and CTLA‐4↓Cardiomyocyte apoptosis↓Infarct size↑Left ventricular function	60, 61