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Squamous cell carcinoma of the uterine cervix, metastatic to the brain: marked anaplasia and extensive keratinization of tumor cells. H and E ×200 (a) and ×400 (b). Note the sharp demarcation between tumor tissue and the surrounding compressed cerebral parenchyma. H and E, ×400 (c). Immunohistochemical stains. Tumor cells are strongly positive for CK7 and CK5/6, ×400 (d and e). In-situ hybridization for HPV (f)
