Table 2.
Difference of means over time among study arms
| A | B | C | p-values | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean observed change from baseline | n | Mean observed change from baseline | n | Mean observed change from baseline | Time vs. arm | Arm | Time | ||
| PHQ-9 | d45 | 18 | 1.17 (5.71) | 21 | 1.9 (5.03) | 19 | −0.53 (4.44) | 0.497 | 0.780 | 0.029 |
| d90 | 14 | 0.21 (4.89) | 19 | 1.95 (5.86) | 18 | 0.94 (4.12) | ||||
| d120 | 14 | 2.86 (6.7) | 16 | 3.12 (6.09) | 17 | −0.76 (5.87) | ||||
| d180 | 12 | 2 (7.59) | 12 | 3.83 (4) | 14 | 2.07 (3.69) | ||||
| HADS-Anxiety | d45 | 18 | 1.56 (3.09) | 21 | 1.9 (3.91) | 19 | 0.89 (4.37) | 0.659 | 0.771 | <0.001 |
| d90 | 14 | 1.64 (4.05) | 19 | 1 (4.88) | 17 | 1.24 (5.66) | ||||
| d120 | 13 | 2.31 (2.93) | 16 | 2.87 (3.26) | 16 | 1.13 (5.12) | ||||
| d180 | 12 | 1.25 (3.89) | 11 | 3.18 (2.79) | 14 | 3.50 (3.16) | ||||
| HADS-Depression | d45 | 17 | 0.65 (3.12) | 21 | 2.05 (3.73) | 19 | 2.11 (3.73) | 0.188 | 0.854 | 0.017 |
| d90 | 14 | −0.43 (3.41) | 19 | 1.11 (5.02) | 18 | 2.44 (3.65) | ||||
| d120 | 14 | 0 (2.69) | 16 | 2.69 (4.74) | 17 | 1.12 (4.77) | ||||
| d180 | 12 | −1.08 (4.46) | 12 | 1.83 (4.06) | 14 | 2.79 (4.04) | ||||
| ESAS- Anxiety | d45 | 18 | 2.11 (3.5) | 21 | 1.48 (2.52) | 19 | 0.95 (3.42) | 0.687 | 0.966 | <0.001 |
| d90 | 14 | 1.71 (2.46) | 19 | 1.58 (3.95) | 18 | 1.17 (3.33) | ||||
| d120 | 14 | 2.93 (3.17) | 16 | 2.13 (2.68) | 17 | 0.59 (4.06) | ||||
| d180 | 12 | 2.92 (3.20) | 12 | 2.42 (2.43) | 14 | 1.36 (3.20) | ||||
| ESAS-Depression | d45 | 18 | 0.11 (3.01) | 21 | 0.48 (1.89) | 19 | 0.37 (1.3) | 0.393 | 0.650 | 0.520 |
| d90 | 14 | 0.21 (3.75) | 19 | 0.42 (1.68) | 18 | 0.06 (2.88) | ||||
| d120 | 14 | 0.57 (2.31) | 16 | 0.25 (1.73) | 17 | −0.82 (3) | ||||
| d180 | 12 | 0.25 (2.09) | 12 | 0.42 (1) | 14 | 0.43 (1.91) | ||||
| ESAS- Emotional domain | d45 | 18 | 2 (4.17) | 21 | 1.95 (3.07) | 19 | 1.32 (4.57) | 0.516 | 0.825 | 0.001 |
| d90 | 14 | 1.93 (5) | 19 | 1.16 (4.54) | 18 | 1.22 (5.77) | ||||
| d120 | 14 | 3.5 (3.98) | 16 | 2.38 (3.59) | 17 | 0.24 (6.69) | ||||
| d180 | 12 | 3.17 (2.55) | 12 | 2.83 (2.72) | 14 | 1.79 (4.69) | ||||
| EORTC QLQC-15Pal Total | d45 | 17 | −5.88 (18.58) | 21 | −7.14 (24.48) | 19 | −15.79 (32.62) | 0.276 | 0.626 | 0.023 |
| d90 | 14 | 4.76 (23.96) | 19 | −7.02 (16.02) | 18 | −12.04 (21.24) | ||||
| d120 | 14 | −2.38 (22.51) | 16 | −4.17 (28.87) | 17 | −16.67 (30.05) | ||||
| d180 | 12 | 0 (22.47) | 12 | 2.78 (35.41) | 14 | −20.24 (27.09) | ||||
| EORTC QLQC-15Pal Emotional domain | d45 | 18 | −17.59 (29.96) | 21 | −8.73 (21.49) | 19 | −7.89 (28.53) | 0.352 | 0.877 | 0.005 |
| d90 | 14 | −20.24 (29.37) | 19 | −3.51 (21.93) | 18 | −3.70 (26.54) | ||||
| d120 | 14 | −22.62 (26.64) | 16 | −8.33 (29.81) | 17 | 3.92 (36.1) | ||||
| d180 | 12 | −16.67 (30.15) | 12 | −15.28 (15.01) | 14 | −9.52 (38.52) | ||||