Table 3.

Difference in means and effect size among study arms

Instrument	Assessed domain	Comparison among study arms
		A vs. B				A vs. C				B vs. C
		Δ A	Δ B	ES	p*	Δ A	Δ C	ES	p*	Δ B	Δ C	ES	p*
EORTC QLQ-C15 Pal	Global health	−4.76	−8.88	0.20	0.953	−4.76	−11.76	0.31	0.984	−8.88	−11.76	0.15	0.946
	Emotional functioning	−20.24	−2.94	−0.66	0.200	−20.24	−2.94	−0.61	0.138	−2.94	−2.94	0.00	0.734
HADS	Anxiety	1.64	0.82	0.17	0.984	1.64	0.88	0.15	0.951	0.82	0.88	−0.01	0.958
	Depression	−0.43	1.06	−0.33	0.336	−0.43	2.18	−0.74	0.029	1.06	2.18	−0.25	0.394
PHQ9	Depression	1.14	2.71	−0.26	0.356	1.14	0.88	0.05	0.710	2.71	0.88	0.32	0.231
ESAS	Anxiety	1.93	0.88	0.22	0.710	1.93	0.88	0.19	0.173	0.88	0.88	0.00	0.290
	Depression
	Emotional	1.93	0.88	0.22	0.710	1.93	0.88	0.19	0.173	0.88	0.88	0.00	0.290

Legend: ES effect size; Δ = difference in means between days 0 and 90 (d0-d90)

*Mann-Whitney test (Bonferroni correction; values are significant when p < 0.017)