Table 1.
Thirteen reported cases of spinal infection due to Parvimonas micra
| Case | Age | Sex | Underlying disease | Sample | Method for definitive diagnosis | Antimicrobial therapy | Outcome | Year | Reference number |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 70 | M | Prostatauxe | Needle-biopsy sampling of vertebral disk | Culture | 6 weeks of i.v. CLDM | Recovered | 1986 | 15 |
| 2 | 70 | M | Ulcerative colitis | Cerebrospinal fluid specimen | Culture | 4 weeks of i.v. penicillin and 4 weeks of oral AMPC in addition to Metronidazole | Recovered | 2000 | 16 |
| 3 | 84 | M | Periodontitis | Surgical bone sampling | 16S rRNA sequencing | 8 weeks i.v. ABPC/SBT and 4 weeks of oral AMPC/CVA |
Recovered | 2014 | 3 |
| 4 | 85 | F | Periodontitis | Blood culture | Culture | 12 days of i.v. Doripenem and 4 weeks of i.v. ABPC, 8 weeks of oral AMPC | Recovered | 2014 | 3 |
| 5 | 49 | M | After dental extraction Spinal instrumentation |
Surgical bone sampling | Culture, MALDI-TOF mass | 6 weeks of i.v. CTRX and oral Metronidazole |
Recovered | 2015 | 5 |
| 6 | 72 | M | After dental extraction | Needle biopsy sampling of vertebral disk | Culture, 16S rRNA sequencing | 6 weeks of i.v. PIPC/TAZ and 2 weeks of oral AMPC/CVA |
Recovered | 2015 | 6 |
| 7 | 72 | F | Chronic osteoarthritis | Epidural abscess | Culture, MALDI-TOF mass | 4 weeks of i.v. PIPC/TAZ | Recovered | 2015 | 6 |
| 8 | 83 | M | Ischemic heart disease | Surgical bone sampling and blood culture |
Culture, MALDI-TOF mass | 15 days of i.v. AMPC + GEM and 12 weeks of oral CLDM + RFP |
Recovered | 2015 | 7 |
| 9 | 55 | F | After dental treatment | Epidural abscess | Culture and MALDI-TOF mass, 16S rRNA sequencing | 6 weeks of i.v. ABPC/SBT and 10 weeks of oral Metronidazole | Recovered | 2015 | 8 |
| 10 | 59 | F | Dental caries with an apical granuloma | Blood culture | Culture | 14 weeks of oral AMPC | Recovered | 2015 | 17 |
| 11 | 82 | F | Dental apical granuloma | Blood culture | Culture | i.v. CTRX + GEM and oral AMPC (total 6 weeks) |
Recovered | 2015 | 17 |
| 12 | 60 | F | Unknown | Blood culture | Culture | i.v. CTRX + GEM and oral AMPC (total 12 weeks) |
Recovered | 2015 | 17 |
| 13 | 67 | M | Periodontitis, Diabetes mellitus |
Needle biopsy sampling of vertebral disk and blood culture |
Culture, MALDI-TOF mass and Tm mapping method | 2 weeks of i.v. ABPC/SBT and 8 weeks of i.v. ABPC | Recovered | 2015 | Present case |
MALDI-TOF mass Matrix-assisted laser desorption ionization-time of flight mass spectrometry, Tm melting temperature, i.v. intravenous, CLDM clindamycin, ABPC ampicillin, ABPC/SBT ampicillin/sulbactam, AMPC amoxicillin, AMPC/CVA amoxicillin/clavulanic acid, CTRX ceftriaxone, PIPC/TAZ piperacillin/tazobactam, GEM gentamicin, RFP rifampin