(b) Bioclinical and gene expression analysis after HTT

HTT		Glycemia (mg/dL)	Insulin (U/mL)	TC (mg/dL)	HDL-C (mg/dL)	Tg (mg/dL)	LDL-C (mg/dL)	HT (mg/mL)	TAS (mM)	Thiols (μM)	Nitrites (μM)	Nitrates (μM)	MDA (μM)	SOD1
Glycemia (mg/dL)	ρ		−0.46	0.54	−0.68	−0.64	0.73	−0.11	0.64	−0.32	0.41	−0.43	0.14	−0.36
	p		0.29	0.21	0.09	0.12	0.07	0.81	0.12	0.48	0.36	0.34	0.77	0.43
Insulin (U/mL)	ρ			−0.10	−0.02	0.58	−0.16	0.53	−0.51	−0.25	0.15	0.65	−0.13	0.32
	p			0.83	0.97	0.17	0.73	0.22	0.25	0.59	0.76	0.11	0.78	0.48
TC (mg/dL)	ρ				−0.07	−0.02	0.94	0.44	−0.04	−0.13	0.68	−0.71	−0.02	−0.29
	p				0.88	0.96	0.001∗	0.32	0.94	0.78	0.09	0.07	0.97	0.53
HDL-C (mg/dL)	ρ					0.23	−0.39	0.17	−0.32	0.32	−0.15	−0.17	−0.25	0.21
	p					0.62	0.39	0.71	0.48	0.48	0.75	0.72	0.59	0.65
Tg (mg/dL)	ρ						−0.08	0.41	−0.98	0.46	0.08	0.19	−0.35	−0.05
	p						0.87	0.37	0.001∗	0.30	0.86	0.69	0.44	0.92
LDL-C (mg/dL)	ρ							0.36	0.06	−0.10	0.71	−0.67	0.01	−0.45
	p							0.43	0.90	0.82	0.07	0.10	0.99	0.31
HT (mg/mL)	ρ								−0.34	0.26	0.84	−0.17	−0.47	−0.46
	p								0.45	0.57	0.02∗	0.71	0.29	0.30
TAS (mM)	ρ									−0.44	−0.03	−0.12	0.37	−0.02
	p									0.32	0.94	0.79	0.42	0.97
Thiols (μM)	ρ										0.22	−0.34	−0.57	−0.70
	p										0.64	0.46	0.18	0.08
Nitrites (μM)	ρ											−0.46	−0.47	−0.71
	p											0.30	0.28	0.07
Nitrates (μM)	ρ												−0.02	0.56
	p												0.96	0.19
MDA (μM)	Ρ													0.46
	p													0.30

Analysis was conducted using Pearson or Spearman's rank correlation coefficient ρ. Statistical significance attributed to results with ^∗p < 0.05. HTT: hydroxytyrosol treatment; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; Tg: triglycerides; LDL-C: low-density lipoprotein cholesterol; TAS: total antioxidant status; SOD1: superoxide dismutase 1.