Fig A4.

Cases of AML misclassified as T-ALL. (A,C) Cross-validation training dataset from stage I. (B,D) Independent test data from stage II. There are recent data available that AML cases with CEBPA silencing have T-lineage features and exhibit a distinctive gene expression profile³⁷ (Wouters BJ et al: Blood 113:3088-3091, 2009). Hypermethylation of the proximal CEBPA promoter was identified in a small subset of AMLs with low CEBPA mRNA expression.³⁷ Here, an analysis was performed to investigate the gene expression intensity of CEBPA and a correlation with misclassification of AML cases by the microarray prediction algorithm into the category of T-ALL. The identity of the corresponding cases is given in Table A3.