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Total cohort n = 14 610 |
Patients who completed diaries and where prescribing strategy known n = 1512 |
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| Not given antibiotics | Given antibiotics | Delayed antibiotics | Not given antibiotics | Given antibiotics | Delayed antibiotics | |
| Clinical assessment | ||||||
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| Number in cohort | 6057 | 6089 | 2464 | 587 | 728 | 197 |
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| Severity of sore throat/difficulty swallowing on a 4-point Likert scale, mean (SD) | 2.93 (0.72) | 3.32 (0.63) | 3.06 (0.70) | 2.93 (0.68) | 3.35 (0.63) | 3.01 (0.68) |
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| Severity of all baseline symptomsa on 4-point Likert scale, mean (SD) | 1.89 (0.39) | 2.19 (0.39) | 1.99 (0.40) | 1.88 (0.40) | 2.21 (0.38) | 1.95 (0.36) |
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| Mean FeverPAIN score, mean (SD) | 0.33 (0.58) | 1.21 (1.09) | 0.72 (0.84) | 0.26 (0.52) | 1.19 (1.11) | 0.73 (0.84) |
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| Prior duration in days, mean (SD) | 4.96 (6.48) | 4.61 (4.10) | 4.29 (3.34) | 4.75 (4.14) | 4.57 (3.39) | 4.17 (3.15) |
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| Age in years, mean (SD) | 34.72 (15.44) | 32.65 (14.18) | 34.07 (14.57) | 37.61 (15.47) | 36.04 (13.85) | 35.68 (14.15) |
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| Female sex, n/N (%) | 3610/5243 (68.85) | 4147/6269 (66.15%) | 1770/2501 (70.77%) | 443/587 (75.47%) | 521/728 (71.57%) | 147/197 (74.62%) |
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| Smoker, n/N (%) | 1016/5212 (19.49) | 1445/6240 (23.16%) | 481/2484 (19.36%) | 89/594 (15.24%) | 127/726 (17.49%) | 22/194 (11.34%) |
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| Fever in last 24 hours, n/N (%) | 2279/4852 (46.97) | 4109/5704 (72.04%) | 1268/2317 (54.73%) | 261/585 (44.62%) | 515/724 (71.13%) | 113/197 (57.36%) |
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| Temperature ºC (SD) | 36.66 (0.61) | 37.00 (0.75) | 36.77 (0.62) | 36.64 (0.61) | 36.99 (0.74) | 36.74 (0.50) |
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| Pus on tonsils, n/N (%) | 376/5213 (7.21) | 3751/6232 (60.19%) | 654/2495 (26.21%) | 30/581 (5.16%) | 418/721 (57.98%) | 50/197 (25.38%) |
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| Severely inflamed tonsils, n/N (%) | 86/4923 (1.75) | 1418/5855 (24.22%) | 178/2344 (7.59%) | 6/572 (1.05%) | 181/720 (25.14%) | 12/191 (6.28%) |
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| Number of prior medical problems | 0.22 (0.49) | 0.24 (0.51) | 0.17 (0.43) | 0.28 (0.55) | 0.24 (0.51) | 0.17 (0.39) |
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| Return within 4 weeks with new or worsening symptoms, n/N (%) | 803/4974 (16.14) | 864/5932 (14.57%) | 222/2382 (9.49%) | 107/564 (18.97%) | 101/694 (14.55%) | 24/186 (12.90%) |
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| Return within 4 weeks with complications, n/N (%) | 75/4974 (1.51) | 78/5932 (1.31%) | 21/2382 (0.88%) | 12/564 (2.13%) | 8/694 (1.15%) | 3/186 (1.15%) |
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| Individual complications, n/N (%) | ||||||
| Quinsy | 11/4974 (0.22) | 30/5932 (0.52%) | 6/2382 (0.26%) | 4/564 (0.71%) | 3/694 (0.43%) | 1/186 (0.54%) |
| Sinusitis | 23/4974 (0.46) | 12/5932 (0.21%) | 3/2382 (0.13%) | 2/564 (0.35%) | 0/694 | 0/186 |
| Otitis media | 31/4974 (0.62) | 27/5932 (0.47%) | 11/2382 (0.47%) | 5/564 (0.89%) | 5/694 (0.72%) | 2/186 (1.08%) |
| Celluliltis/impetigo | 10/4974 (0.20) | 9/5932 (0.16%) | 1/2382 (0.04%) | 1/564 (0.18%) | 0/694 | 0/186 |
a
Baseline severity comprised of: sore throat, difficulty swallowing, feeling generally unwell, headache, disturbed sleep, muscle ache, fever during illness, fever in the last 24 hours, abdominal pain, diarrhoea, cough during illness, vomiting, runny nose, earache, inflamed pharynx, inflamed tonsils, cervical glands.