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Study and treatment flow chart. The interval between each scheduled follow-up is one month. Break time is the mean time that passed after surgery, when patients return to the Out-Patient Center of Rheumatology and Pain Therapy complaining of persistent and increased pain. TPD: tapentadol; PGB: pregabalin; um-PEA: ultramicronized palmitoylethanolamide; SD: standard deviation.
