Fig. 1.

Topology model of TSHR with location of confirmed or putative inactivating mutations identified in subjects with RTSH. Missense mutations are indicated in orange, nonsense mutations in red, insertions/deletions in the coding sequence in yellow, and intronic mutations in blue. Residues forming the beta strands of the leucine-rich repeats within the extracellular ligand-binding domain are marked by green arrows. SP, signal peptide sequence (removed in mature protein).