Fig. 3.

Autosomal-dominant RTSH linked to a locus on the long arm of chromosome 15. A) Multipoint genetic linkage analysis of chromosome 15 in five extended families with dominant inherited RTSH. The analysis shown includes data from additional family members not available in the original publication [90]. B) Example of fine mapping of the critical recombinants in family 25 using short tandem repeat markers. The RTSH-associated haplotype can be narrowed to a 2.9 megabase interval containing sixteen positional candidate genes. Note that common single nucleotide polymorphisms within the central micro RNA cluster (mir7-2, mir1179) have recently been found to be significantly associated with serum TSH level in the general population [91, 92]. Adapted from ref. [90] with permission.