Figure 5. Loss of Gpr37L1 but not Gpr37 in vivo increases susceptibility to flurothyl-induced seizures.

(A & B) Gpr37L1^−/− mice exhibited decreased latency to first myoclonic jerk (MJ) and generalized tonic-clonic seizure (GTCS) compared to WT littermates. Latency to the MJ and GTCS were comparable between Gpr37L1^−/− and DKO mice. Gpr3T^−/− mice were not significantly different from WT littermates. One-way ANOVA, Dunnett’s post hoc, *p < 0.001, 10–42 animals/genotype.