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. 2001 Jun 1;29(11):2349–2360. doi: 10.1093/nar/29.11.2349

Figure 6.

Figure 6

Increased misincorporation of dUMP into DNA promotes the association of APE2 and PCNA in nuclear foci. HeLa MRV cells were incubated in medium supplemented with (B and D) or without (A and C) HAT and dUrd for 6 h. The cells were immunostained with anti-APE2/Alexa Fluor 488-labeled second antibody and anti-PCNA/Alexa Fluor 594-labeled second antibody and were subjected to laser scanning fluorescence microscopy. The APE2 and PCNA signals are shown in green and red, respectively, and the co-localized signals are shown in yellow (A and B). The nuclei were counterstained with TOTO-3 (C and D).