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. 2017 May 4;45(13):e122. doi: 10.1093/nar/gkx338

Figure 8.

Figure 8.

FOXA1 and FOXC1 mRNA levels define two main sub-populations of tumours corresponding to basal-like versus other tumour types. (A) Minimal spanning tree for the ‘luminal’ cluster. Transcription factor-encoding genes, AR, ESR1, FOXA1, GATA3, SPDEF and XBP1 are highlighted in orange. (B) Waterfall analysis of FOXA1 most correlated and anti-correlated genes. FOXA1 and FOXC1 are highlighted in blue. (C). Breast tumours were sorted according to expression levels of FOXA1 and FOXC1, revealing two main groups of tumours. FOXA1hiFOXC1lo tumours include the lumA, lumB, HER2+ and normal-like groups, while the FOXA1loFOXC1hi group coincides with basal-like tumours.