Table 2.

Alterations in protein expression by protracted low-dose-rate irradiation of mouse livers

Protein	Fold change (mean ± SD)	P	Related functions
Immediately after total dose irradiation with 8 Gy
MBNL1	3.3 ± 0.2	<0.01	Gene expression and regulation
Laminin2 α2	2.6 ± 0.4	<0.01	Basement membrane
DRAK1	0.23 ± 0.09	<0.01	Apoptosis
PUMA/bbc3	0.36 ± 0.11	<0.01	Apoptosis
BID	0.27 ± 0.05	<0.01	Apoptosis
cRaf (pSer621)	0.4 ± 0.09	<0.01	MEK signaling
Bim	0.41 ± 0.07	<0.01	Apoptosis
Bmf	0.34 ± 0.09	<0.01	Apoptosis
SynCAM	0.45 ± 0.05	<0.01	Cell–Cell adhesion
ILP2	0.43 ± 0.02	<0.01	Apoptosis
3 months after total dose irradiation with 8 Gy
Laminin2 α2	4.3 ± 2.9	0.063	Basement membrane
NFκB	16 ± 20	0.131	Gene expression and regulation
Caspase12	3.3 ± 0.9	<0.01	Apoptosis
Phosphor-β-catenin (pSer45)	2.7 ± 1.0	<0.05	Cytoskeleton
DRAK1	0.29 ± 0.1	<0.01	Apoptosis
BID	0.31 ± 0.04	<0.01	Apoptosis
Bim	0.35 ± 0.07	<0.01	Apoptosis
Bmf	0.33 ± 0.06	<0.01	Apoptosis
Apaf1	0.34 ± 0.06	<0.01	Apoptosis

Alterations were observed in expression of the proteins in boldface type both immediately and at 3 months after irradiation.