Figure 5.
Effects of zolmitriptan, a 5-HT1B/1D receptor agonist, on infusions (A,C), and active lever (B,C) responses on a VR5 schedule of methamphetamine (0.1 mg/kg, i.v.) reinforcement during pre- and postabstinence tests (left and right panels, respectively). Data are expressed as the mean (±SEM). Rats were pretreated 15 minutes prior to the start of the 2-hour sessions with either vehicle (white bar/open circles; n = 6) or zolmitriptan (10 mg/kg, s.c.; black bar/filled squares; n = 9). Asterisks (*) represent a difference from vehicle condition (t test or ANOVA main effect, P<.05).