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Analysis of mutations (amino acid replacements) in the context of the HIV-1 integrase protein structure. Change in energy (ΔΔG) for all amino acid replacements found in regions of known protein structure, as predicted using a statistical potential. Each boxplot represents a distribution of energy changes to all 19 other residue types at positions where a non-synonymous substitution has been observed. The ΔΔG of the observed substitution is indicated in red.
