Fig. 5.

—Principal component regression analysis on the yeast, fly, and worm protein–protein interaction networks. For each principal component (PC), the size of the bar represents the percent of the variability of the response variable explained by the PC. The composition of each component is represented in colors. Network parameters are highlighted within black boxes. PCR analyses were restricted to the genes for which data were available for all variables (2,429 for yeast, 3,880 for fly, and 608 for worm).