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. 2017 Jun 7;45(13):7581–7592. doi: 10.1093/nar/gkx507

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — 5΄ -(E)-vinylphosphonate modification enhances hsiRNA efficacy in liver, kidneys and heart column scatter plots showing Ppib or Htt mRNA levels in the livers, kidneys and hearts of mice (n = 5 per group) treated with 5΄-hydroxyl (5΄-OH), 5΄-phosphate (5΄-P), or and 5΄-(E)-vinylphosphonate (5΄-VP) hsiRNAs by intravenous (IV) of subcutaneous (SC) injection. mRNA levels measured by QuantiGene^® 2.0 assay, were normalized to Hprt mRNA and expressed as percent of mRNA levels in PBS-treated animals. NTC, non-targeting control. T, targeting hsiRNA. Significance calculated by ANOVA with Bonferroni΄ s correction: ns, non-significant; *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001 and ****P ≤ 0.0001.

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