Table 3.
Comparison of Initial and Peak CMV VL in PL and WB Based on Symptomatic and Asymptomatic Disease
| Patient Group | Overall Median VL (IU/mL)a | Symptomatic | Asymptomatic | P Valueb | ||
|---|---|---|---|---|---|---|
| N | Median VL (IU/mL)a | N | Median VL (IU/mL)a | |||
| All Patients | ||||||
| Initial VL, PL | 954 (363, 4880) | 29 | 4880 (1570, 20800) | 54 | 470 (290, 1140) | <.001 |
| Initial VL, WB | 5480 (1740, 18200) | 29 | 14800 (1990, 85400) | 54 | 5000 (1040, 8250) | .005 |
| Peak VL, PL | 1380 (442, 5690) | 31 | 5450 (1570, 20800) | 57 | 825 (363, 2030) | <.001 |
| Peak VL, WB | 6240 (2020, 22400) | 31 | 27600 (2900, 100000) | 57 | 5350 (1630, 11600) | .002 |
| SOT Patients | ||||||
| Initial VL, PL | 1700 (428, 12500) | 20 | 9100 (2830, 32200) | 23 | 606 (297, 2530) | <.001 |
| Initial VL, WB | 6280 (1974, 30300) | 20 | 35200 (2440, 237000) | 23 | 4520 (779, 8870) | .004 |
| Peak VL, PL | 2280 (434, 13400) | 22 | 9100 (1700, 26300) | 24 | 863 (355, 3960) | .003 |
| Peak VL, WB | 7144 (2050, 36600) | 22 | 35200 (5080, 101000) | 24 | 5271 (1210, 9130) | .002 |
| HSCT Patients | ||||||
| Initial VL, PL | 537 (302, 1550) | 9 | 2790 (1530, 3870) | 31 | 466 (281, 954) | <.001 |
| Initial VL, WB | 5190 (1280, 9930) | 9 | 5550 (1740, 14800) | 31 | 5130 (1040, 8250) | .734 |
| Peak VL, PL | 1120 (449, 3230) | 9 | 3220 (1570, 4880) | 33 | 825 (414, 1900) | .016 |
| Peak VL, WB | 5520 (1740, 17900) | 9 | 6200 (1740, 37900) | 33 | 5350 (3190, 15000) | .490 |
Abbreviations: CMV, cytomegalovirus; HSCT, hematopoietic stem cell transplant; PL, plasma; SOT, solid organ transplant; VL, viral load; WB, whole blood.
aNumbers in parenthesis represent the 25th and 75th percentile values (ie, interquartile range).
bWilcoxon rank-sum test.