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. 2017 May 10;45(13):7708–7721. doi: 10.1093/nar/gkx373

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Temporal control of meiotic splicing by Snf2. (A) Upon shift into sporulation media, Ume6 is degraded and Snf2 is deacetylated. This contributes to its relocalization to the MER1 promoter from the RPGs in a manner correlated with H3K9ac. Snf2 reverses Ume6-dependent repression at the MER1 promoter and MER1 mRNA levels rise. (B) Snf2 regulates RPG transcription, such that under vegetative growth conditions, high levels of RPGs titrates away the free pool of active spliceosomes. Ume6 represses expression of meiotic transcripts. Upon shift to sporulation media and the establishment of favorable conditions for MER1 transcription (see panel A), Snf2 is downregulated, which is correlated with repressed RPG expression and the freeing up of active spliceosomes to increase splicing and expression of the meiotic RNAs.