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Flanking RGG/RG domains impart the RNA binding activity of the RRM. (A) Representative EMSAs and (B) the corresponding binding curves showing binding of DNMT RNA to RGG1-RRM (165–373), RRM-RGG2 (267–422), RGG1-RRM-RGG2 (165–422) proteins. b = bound and f = free RNA. ‘(−)’ shows no protein lane. Error bars represent the S.D. of three independent titrations for each construct.
