Figure 5.

RGG/RG domains represent moderate preference for structured RNAs. Heat-map for affinity of RGG/RG domains and FUS constructs for each RNA. EMSA experiments were performed with DNMT and Sc1 RNAs containing G-quadruplexes, hRRD and mRRD RNAs with complex secondary structures, dsAU and dsGC simple double stranded RNAs, and GGUG, CRL and poly-A single stranded RNAs. K_D,app (μM) was represented with a color code for all combinations of RNA–protein with a data range from two or more independent experiments.