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. 2017 Apr 10;45(Web Server issue):W422–W428. doi: 10.1093/nar/gkx249

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Four examples of CASP12 targets where using ReFOLD allowed us to fix errors in the top selected server model. Left panels, refined model with ModFOLD6 accuracy self assessment (ASE) displayed using the temperature colour scheme. Middle panels, superposition of the top selected server model (cyan), refined model (magenta) and native structure (green). Right panels, GDT plots comparing top selected server models (cyan) with the ReFOLD refined models (magenta). (A) FM target T0918 domain 1: QUARK_TS1 versus McGuffin_TS1, a GDT_TS improvement from 45.6 to 48.38. (B) FM/TBM target T0912 domain 2: GOAL_TS1 versus McGuffin_TS1, GDT_TS from 62.95 to 65.36. (C) TBM target T0872 domain 1: IntFOLD4_TS1 versus McGuffin_TS1, GDT_TS from 66.76 to 67.9 (D) TR945: starting model versus McGuffin_TS1, GDT_TS from 59.27 to 61.20. Models are rendered using PyMOL (http://www.pymol.org). GDT plots are from http://www.predictioncenter.org/casp12/.