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. 2017 Jun 21;45(13):7602–7614. doi: 10.1093/nar/gkx546

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Mathematical modeling predicts the existence of an affinity optimum that maximizes silencing. (A) Schematic of mathematical model. Mass action kinetics was used to describe the delivery of siRNA between extracellular, endosomal and cytoplasmic compartments. The concentrations of free siRNA, free carrier and the siRNA-carrier complex were tracked separately in each compartment. Ø indicates degradation. (B) The predicted dependence of silencing potency on the dissociation rate between siRNA and its carrier. All other parameters were held constant, including the rate of endosomal release and the initial extracellular concentration of siRNA.