Fig. 4.

Association of chromosome 1q gain and telomerase reactivation in PF-EPN-A. (A) Telomerase activity and (B) hTERT mRNA expression levels segregated according to chromosome 1q gain. One single case with gain of chromosome 5p is indicated. The dotted line at zero highlights negative samples. (C) GSEA for the term “Reactome Telomere Maintenance.” TRAP gels and copy number profiles are shown for a 1q gain–negative (D, E) and a 1q gain–positive (F, G) tumor. Statistical analyses were performed by a Mann–Whitney U test (**P < .01); pos, positive; neg, negative; TPG, total product generated; M, marker; NTC, no template control; A, active sample; H, heat inactivated sample.