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Visualization of c-KIT tyrosine kinase analysis on Bis2Analyzer. (A) Part of the sequence alignment where cluster 9 is localized. (B) Description of the three hits comprising cluster 9. (C) Display of cluster 9 on c-KIT inactive form (left, 1T45) and on its active form (right, 1PKG). Note that the active form has an unfolded N-terminal that has been partially removed in the crystal (right). (D) Plot of cluster 9 (green dots) on a multiple sequence alignmen (MSA) sequence.
