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. 2017 Apr 21;45(Web Server issue):W138–W145. doi: 10.1093/nar/gkx302

Figure 3.

Figure 3.

Genes affecting the face, the brain, and the urogenital and skeletal systems are over-represented on chromosome X. (A) A heat map of enriched and depleted organs within X-linked genes. Gene ORGANizer detects significant enrichment of the brain and testes within these genes, confirming previous claims. A more pronounced trend is the over-representation of different facial features, including all parts of the face except the eyes. Many parts of the urogenital and skeletal systems are enriched as well. (B) A heat map of enriched and depleted systems within X-linked genes. The reproductive and the skeletal systems are significantly enriched (×1.38 and ×1.12, FDR = 3 × 10−5 and 0.022, respectively). The immune and the cardiovascular systems are significantly depleted (×0.74 and ×0.87, FDR = 0.002 and 0.032, respectively). (C) A heat map of enriched and depleted body regions within X-linked genes. The regions of the pelvis and limbs are significantly over-represented (×1.22 and ×1.16, FDR = 5 × 10−4 and 0.003, respectively). The abdominal region is significantly depleted (×0.84, FDR = 0.008).