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. 2017 Aug 24;12(8):e0183590. doi: 10.1371/journal.pone.0183590

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Fig 1 — (A) Patella diameter before and 24h after joint bleeding induction to the right knee (n = 7,6) of C57BL/6J and F8^-/y with the left knee (n = 6,6) set as a control. (B) Representative rotational thromboelastometry (ROTEM) graphs of a C57BL/6J and a F8^-/y, illustrating clotting time (green), clot formation time (pink) and clot firmness (blue). (C) Clotting times and (D) clot formation times of C57BL/6J, F8^-/y, and F8^-/y blood samples reconstituted with 2.5 U/ml of human recombinant FVIII (n = 3). All data were expressed as means ± SEM. Statistical comparisons were performed using one-way ANOVA or two-way ANOVA * p< 0.05, ** p<0.01, ***p<0.001.