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. 2017 Aug 24;12(8):e0183327. doi: 10.1371/journal.pone.0183327

Fig 13. RecA ATPase inhibitors.

Fig 13

Many different classes of ATPase inhibitors were tested on RecA and shown to have no effect. a) Suramin was developed in the early 1900s to treat parasitic diseases like African sleeping sickness and is on the World Health Organization’s list of essential medicines. b) Coumemycin is a natural product produced by Streptomyces, which potently inhibits staphylococcus gyrase. c) Curcumin and d) genistein are natural products that have been widely studied as antibiotics and anticancer agents. e) PP2 inhibits tyrosine kinases and has been widely studied as an anticancer agent. f) Tenofovir is an FDA-approved treatment for human immunodeficiency virus 1 (HIV-1) and hepatitis B virus infections. e) 6-HD discovered with SACP is the only selective inhibitor of RecA within this group. Numbers in parentheses are molecular weight for each compound.