Table 1. Statistical results from Spearman correlation analyses between normalised brain tissue area and changes in brain structure size and stiffness with respect to their baseline conditions.

Data is presented graphically in Fig 5.

Spearman correlations (P—values)	All rats	Adults only	Juveniles only
Normalised ventricular system area	P = 0.20	P< 0.0001,r = -1	P = 0.98
Normalised cranial area	P < 0.0001,r = 0.84	P = 0.46	P = 0.0004,r = 0.98
Normalised cortical gray matter thickness	P = 0.35	P = 0.46	P = 0.33
Normalised caudate-putamen area	P = 0.045,r = 0.25	P = 0.046,r = 0.74	P = 0.06
Normalised G* cortical gray matter	P = 0.25	P = 0.40	P = 0.75
Normalised G* caudate-putamen	P = 0.65	P = 0.93	P = 0.10