Table 1. Normalized gene expression in the cochlea from RNA-seq data in multiple studies.
E16[56] | E16[55] | P0[56] | P0[55] | P0[54] | P1[56] | |||||
---|---|---|---|---|---|---|---|---|---|---|
HC | CD-HC | SE | HC | CD-HC | SE | HC | CD-HC | HC | ENHC | |
Prickle1 | 1 | 6.89 | 1 | 1 | 1.443 | 1 | 1 | 4.83 | 1 | 1.66 |
Prickle2 | 0.27 | 0.56 | 0.38 | 0.73 | 0.99 | 0.66 | 0.01 | 0.01 | 14.176 | 12.29 |
Prickle3 | 0.25 | 0.25 | 0.18 | 0.05 | 0.25 | 0.18 | 0.26 | 0.70 | - | - |
Testin | 3.40 | 3.33 | 1.29 | 1.02 | 1.96 | 1.99 | 0.93 | 1.74 | 2.00 | 10.98 |
Vangl1 | 0.01 | 0.04 | 0.68 | 0.03 | 0.04 | 1.43 | 0.01 | 0.007 | 2.688 | 2.31 |
Vangl2 | 0.08 | 0.06 | 1.81 | 0.06 | 0.31 | 2.65 | 1.82 | 1.12 | 18.541 | 26.98 |
Fzd3 | 18.27 | 6.57 | 0.95 | 16.80 | 8.10 | 1.50 | 5.82 | 1.57 | 38.041 | 29.63 |
Fzd6 | 1.61 | 1.01 | 1.23 | 14.51 | 0.49 | 3.43 | 0.01 | 0.01 | 21.859 | 13.29 |
Celsr1 | 0.56 | 0.27 | 2.09 | 0.77 | 0.26 | 5.41 | 14.65 | 1.22 | 6.53 | 5.52 |
Dvl1 | 0.41 | 0.27 | 1.55 | 0.25 | 0.15 | 0.61 | 2.14 | 2.12 | 0.576 | 0.82 |
Dvl2 | 0.81 | 1.41 | 1.03 | 4.74 | 9.44 | 1.02 | 1.77 | 3.30 | 1.99 | 3.42 |
Dvl3 | 0.07 | 0.04 | 1.75 | 0.28 | 0.48 | 1.52 | 3.37 | 2.47 | 3.18 | 3.49 |
RNA-Seq data from 4 studies were compiled and normalized to Prickle1 expression in the hair cells (or sensory epithelium) of the same study. Only expression level at E16, P0 and P1 was analyzed. HC, hair cells; CD-HC, cochlear duct excluding hair cells; SE, sensory epithelium; ENHC, epithelial non-hair cells.