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. 2017 Aug 24;12(8):e0182828. doi: 10.1371/journal.pone.0182828

Fig 3. Transcriptome profiling of WT and Akita hearts using next generation sequencing (NGS) and microarray analyses.

Fig 3

(A) Top-ten upregulated transcriptome in Akita by NGS analyses. (B) Top-ten downregulated transcriptome in Akita heart by NGS analyses. (C) Top-ten upregulated transcriptome in Akita heart by microarray analyses. (D) Top-ten downregulated transcriptome in Akita heart by microarray analyses. (E) Top-ten upregulated genes in Akita heart common in both NGS and microarray analyses (fold change ≤ 2 or 2 ≥ and p-value < 0.05). All the data are represented as fold change of WT hearts. Values are mean ± SD. N = 3. (F-H) Validation of three upregulated genes in Akita heart using an independent experiment and qPCR analyses. Values are represented as mean ± SEM. N = 3.