Table 1. Mutations present in tumour samples.

Comparison	# SNVs	# indels
sibling_tissue_1.vs.control_tissue_1	944	7221
control_tissue_1.vs.tumour_tissue_1	485	1
sibling_tissue_2.vs.control_tissue_2a	995	6959
sibling_tissue_2.vs.control_tissue_2b	1001	9747
control_tissue_2a.vs.tumour_tissue_2a	592	1
control_tissue_2b.vs.tumour_tissue_2b	526	1
sibling_tissue_3.vs.control_tissue_3	866	7829
control_tissue_3.vs.tumour_tissue_3	465	1

Whole exome sequencing was performed on dissected tumours, adjacent non-tumour control tissue and siblings. The number of SNVs and indels detected in sibling vs control tissue and control vs tumour tissue are shown.