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. Author manuscript; available in PMC: 2017 Nov 3.
Published in final edited form as: Nature. 2017 May 3;545(7653):219–223. doi: 10.1038/nature22073

Figure 4. Enhancing MD excitability strengthens PFC rule representation and improves performance.

Figure 4

(a) Optogenetic MD activation causes tuning of previously unturned PFC neurons in the 2AFC delay period, while (b) Optogenetic PFC activation generates inappropriate PFC tuning peaks (shading indicates laser on). (c, d) Quantification of examples in a,b (binomial test). (e) Quantification of existing peak size change (data is mean ± CI) and (f, g) rule information within the PFC following MD or PFC activation (n = 2 mice). (h, i) Opposing performance effects of he two manipulations (n = 16 sessions each from 4 mice).). Shading indicates 95% confidence intervals (see methods). Behavioral data is presented as session averages and compared using Wilcoxon rank-sum test.