Extended Data Figure 2.

Distribution of methylation values at the 187 sentinel CpG sites compared to the ~473K CpG sites assayed by the Illumina Infinium 450K Human Methylation array. The 187 identified methylation-BMI associations are strongly enriched for CpG sites with intermediate levels of methylation, consistent with the presence of epigenetic heterogeneity at these loci in blood (157/187 sites with 20-80% methylation, a 3.0-fold enrichment compared to microarray background, P=1.4x10^-22 Fisher’s test).