Skip to main content
. Author manuscript; available in PMC: 2017 Aug 24.
Published in final edited form as: Nature. 2017 Feb 15;543(7645):433–437. doi: 10.1038/nature21378

Figure 1. SZT2 is essential for mTORC1 inactivation upon nutrient deprivation and functions upstream of Rag GTPases.

Figure 1

a, b and d, Control (sgGFP) or SZT2-deficient (sgSZT2) cells were deprived of amino acids (a, b) or serum (b) for 1 h and stimulated with amino acids (a, b) or serum (b) for 10 min when indicated. Total cell lysates were analyzed by immunoblotting. c, Cells were treated as in (a). The localization of mTOR and Lamp2 was determined by immunostaining. See Extended Data Fig. 1f for statistical analyses. Data (a, b, d) are representatives of three independent experiments.