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. 2017 Aug;14(3):212–227. doi: 10.20892/j.issn.2095-3941.2017.0054

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Copyright 2017 Cancer Biology & Medicine

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Combination of PEGylated, MMP2-activatable cell-penetrating TCS with PTX liposomes for overcoming the drug-resistant lung cancer. (A) Scheme of the PEGylated, MMP2-activatable cell-penetrating TCS combined with PTX for overcoming drug resistance in A549/T cells. (B) In vitro synergistic cytotoxicity of PEGylated, MMP2-activatable cell-penetrating TCS, and PTX. (C) Regulatory effect of PEGylated, MMP2-activatable cell-penetrating TCS and PTX on caspase 9 phosphorylation and caspase 3. (D) Synergistic therapeutic effect of the PEGylated, MMP2-activatable cell-penetrating TCS and PTX liposomes in vivo. Reprinted with permission from Ref. 91.