1.
Clinicopathologic features and BRAF status in CRCs with variable signet ring cell component
| BRAF status | BRAF mutant n=11 (%) | BRAF wild–type n=17 (%) | Total n=28 (%) | P | |
| SRC, Signet-ring cell; pTNM, Pathological TNM. | |||||
| Sex | 0.613 | ||||
| Male | 9 (81.8) | 13 (76.5) | 22 (78.6) | ||
| Female | 2 (18.2) | 4 (23.5) | 6 (21.4) | ||
| Age, mean | 48.7±20.9 | 45.6±20.7 | 0.705 | ||
| Location | 0.997 | ||||
| Right colon | 5 (45.4) | 8 (47.1) | 13 (46.5) | ||
| Left colon | 2 (18.2) | 3 (17.6) | 5 (17.8) | ||
| Rectum | 4 (36.4) | 6 (35.3) | 10 (35.7) | ||
| SRC component (%) | 0.957 | ||||
| 0%–9% | 3 (27.3) | 4 (23.5) | 7 (25.0) | ||
| 10%–24% | 3 (27.3) | 6 (35.3) | 9 (32.1) | ||
| 25%–49% | 1 (9.1) | 2 (11.8) | 3 (10.8) | ||
| ≥50% | 4 (36.4) | 5 (29.4) | 9 (32.1) | ||
| pTNM | 0.538 | ||||
| T3 | 2 (18.2) | 5 (29.4) | 7 (25.0) | ||
| T4 | 9 (81.8) | 12 (70.6) | 21 (75.0) | 0.309 | |
| N0 | 2 (18.2) | 4 (23.5) | 6 (21.4) | ||
| N1 | 2 (18.2) | 1 (5.9) | 3 (10.7) | ||
| N2 | 7 (63.6) | 12 (70.6) | 19 (67.9) | 0.581 | |
| M0 | 8 (72.7) | 13 (76.5) | 21 (75.0) | ||
| M1 | 3 (27.3) | 4 (23.5) | 7 (25.0) | ||
| Stage | 0.893 | ||||
| II | 2 (18.2) | 3 (17.6) | 5 (17.9) | ||
| III | 6 (54.5) | 10 (58.9) | 16 (57.1) | ||
| IV | 3 (27.3) | 4 (23.5) | 7 (25.0) | ||