3.
VDR-BsmI and VDR-FokI genotypes alone or combined with smoking duration and obesity compared between 120 melanoma cases and 120 healthy controls.
| Single or combined variable | Melanoma cases (n=120), n (%) | Healthy controls (n=120), n (%) | OR (CI), P (Melanomas vs. healthy controls) | MetM (n=52), n (%) | NMetM (n=68), n (%) | OR (CI), P (MetM vs. NMetM) | OR (CI), P (MetM vs. healthy controls) | OR (CI), P (NMetM vs. healthy controls) |
| BB | 30 (25.0) | 31 (25.8) | 0.96 (0.53–1.71), 0.882 | 11 (21.2) | 19 (27.9) | 0.69 (0.30–1.62), 0.395 | 0.77 (0.35–1.68), 0.512 | 1.11 (0.57–2.17), 0.753 |
| Bb | 64 (53.3) | 56 (46.7) | 1.31 (0.79–2.17), 0.302 | 24 (46.2) | 40 (58.8) | 0.60 (0.29–1.24), 0.168 | 0.98 (0.51–1.88), 0.951 | 1.63 (0.89–2.98), 0.109 |
| bb | 26 (21.7) | 33 (27.5) | 0.73 (0.40–1.32), 0.294 | 17 (32.7) | 9 (13.2) | 3.18 (1.28–7.91), 0.010 | 1.28 (0.63–2.59), 0.491 | 0.40 (0.18–0.90), 0.024 |
| BB+Bb (B allele) | 94 (78.3) | 87 (72.5) | 1.37 (0.76–2.48), 0.294 | 35 (67.3) | 59 (86.8) | 0.31 (0.13–0.78), 0.010 | 0.78 (0.39–1.58), 0.491 | 2.49 (1.11–5.58), 0.024 |
| Bb+bb (b allele) | 90 (75.0) | 89 (74.2) | 1.04 (0.58–1.87), 0.882 | 41 (78.8) | 49 (72.1) | 1.44 (0.62–3.38), 0.395 | 1.30 (0.59–2.83), 0.512 | 0.90 (0.46–1.75), 0.753 |
| bb plus ≥20 years ever-smoking | 9 (7.5) | 2 (1.7) | 4.78 (1.01–22.6), 0.031 | 7 (13.5) | 2 (2.9) | 5.13 (1.02–25.8), 0.039 | 9.18 (1.84–45.8), 0.004 | 1.79 (0.25–13.0), 0.621 |
| Bb+bb plus ≥20 years ever-smoking | 28 (23.3) | 14 (11.7) | 2.30 (1.14–4.64), 0.017 | 18 (34.6) | 10 (14.7) | 3.07 (1.27–7.41), 0.011 | 4.01 (1.80–8.90), <0.001 | 1.30 (0.55–3.12), 0.549 |
| bb plus BMI >30 kg/m2 | 4 (3.3) | 0 (–) | –a | 3 (5.8) | 1 (1.5) | 4.10 (0.41–40.6), 0.315 | –a | –a |
| Bb+bb plus BMI >30 kg/m2 | 13 (10.8) | 4 (3.3) | 3.52 (1.11–11.1), 0.024 | 8 (15.4) | 5 (7.4) | 2.29 (0.70–7.47), 0.161 | 5.27 (1.51–18.4), 0.008 | 2.30 (0.60–8.88), 0.288 |
| Bb+bb plus ≥20 years ever-smoking, and plus BMI >30 kg/m2 | 9 (7.5) | 1 (0.8) | 9.65 (1.20–77.4), 0.010 | 8 (15.4) | 1 (1.5) | 12.2 (1.47–101), 0.010 | 21.6 (2.63–178), <0.001 | 1.78 (0.11–28.9), 1.00 |
| FF | 47 (39.2) | 54 (45.0) | 0.79 (0.47–1.31), 0.360 | 17 (32.7) | 30 (44.1) | 0.61 (0.29–1.30), 0.204 | 0.59 (0.30–1.17), 0.132 | 0.96 (0.53–1.76), 0.907 |
| Ff | 60 (50.0) | 50 (41.7) | 1.40 (0.84–2.33), 0.195 | 29 (55.8) | 31 (45.6) | 1.50 (0.73–3.11), 0.269 | 1.76 (0.91–3.40), 0.088^ | 1.17 (0.64–2.14), 0.602 |
| ff | 13 (10.8) | 16 (13.3) | 0.79 (0.36–1.72), 0.552 | 6 (11.5) | 7 (10.3) | 1.14 (0.36–3.61), 0.828 | 0.85 (0.31–2.31), 0.746 | 0.75 (0.29–1.91), 0.541 |
| FF+ff (F allele) | 107 (89.2) | 104 (86.7) | 1.27 (0.58–2.76), 0.552 | 46 (88.5) | 61 (89.7) | 0.88 (0.28–2.79), 0.828 | 1.18 (0.43–3.21), 0.746 | 1.34 (0.52–3.44), 0.541 |
| Ff+ff (f allele) | 73 (60.8) | 66 (55.0) | 1.27 (0.76–2.12), 0.360 | 35 (67.3) | 38 (55.9) | 1.62 (0.77–3.45), 0.204 | 1.68 (0.85–3.33), 0.132 | 1.04 (0.57–1.89), 0.907 |
| Continued | ||||||||